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Article

Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.

Journal of virology - 1 Oct 2001

Chattopadhyay D, Ghosh M K, Mal A, Harter M L

Abstract excerpt

A major impediment to successful chemotherapy is the propensity for some tumor cells to undergo cell cycle arrest rather than apoptosis. It is well established, however, that the adenovirus E1A protein can sensitize these cells to the induction of apoptosis by anticancer agents. To further understand how E1A enhances chemosensitivity, we have made use of a human colon carcinoma cell line (HCT116) which typically...

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Identifiers

PMID: 11559818
DOI: 10.1128/JVI.75.20.9844-9856.2001
PMCID: PMC114557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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