Suppression of adenovirus type 5 E1A-mediated transformation and expression of the transformed phenotype by caffeic acid phenethyl ester (CAPE).

doi:10.1002/mc.2940040310

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Article

Suppression of adenovirus type 5 E1A-mediated transformation and expression of the transformed phenotype by caffeic acid phenethyl ester (CAPE).

Molecular carcinogenesis - 1 Jan 1991

Su Z Z, Grunberger D, Fisher P B

Abstract excerpt

Viral transformation and DNA-transfection assays were employed to investigate the differential toxic effect of caffeic acid phenethyl ester (CAPE), an extract of the honeybee hive product propolis, on adenovirus type 5 (Ad5)-transformed cloned rat embryo fibroblast (CREF) cells. CAPE inhibited, in a dose-dependent manner, both de novo and carcinogen-enhanced transformation of CREF cells by H5hr1, the...

Topics

Actins
Adenoviridae
Adenovirus Early Proteins
Animals
Caffeic Acids
Cell Line
Cell Line, Transformed
Cell Transformation, Viral
Cold Temperature
DNA
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Viral

Methyl Methanesulfonate

Mice

Mutation

Oncogene Proteins, Viral

Phenotype

Phenylethyl Alcohol

Source

Open in PubMed

Identifiers

PMID: 1712205
DOI: 10.1002/mc.2940040310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1712205-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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