Lack of correlation between p53 protein level and sensitivity of DNA-damaging agents in keratinocytes carrying adenovirus E1a mutants.

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Article

Lack of correlation between p53 protein level and sensitivity of DNA-damaging agents in keratinocytes carrying adenovirus E1a mutants.

Oncogene - 17 Aug 1995

Sanchez-Prieto R, Lleonart M, Ramón y Cajal S

Abstract excerpt

p53 tumor suppressor protein is required for efficient execution of apoptosis after DNA-damage in many cell systems. Since the oncogene E1a confers susceptibility to DNA-damaging agents and stabilizes p53 protein, we investigate whether the sensitivity to anticancer drugs of E1a-expressing cells...

Topics

Adenovirus E1A Proteins
Animals
Apoptosis
Blotting, Western
Cell Line, Transformed
Cisplatin
DNA Damage
DNA Replication
Dose-Response Relationship, Drug
Doxorubicin
Gamma Rays
Keratinocytes
Mice
Mutation
Oncogenes
Transfection
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 7651731

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7651731-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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