Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene.

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Article

Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene.

Oncogene - 5 Sept 1996

Sánchez-Prieto R, Quintanilla M, Cano A, Leonart M L, Martin P, Anaya A, Ramón y Cajal S

Abstract excerpt

Squamous cell carcinomas can show different oncogenic alterations, histological patterns, and an unpredictable clinical behavior. We previously reported that the adenovirus E1a gene may induce sensitivity to DNA-damaging agents in mouse keratinocytes. In order to study whether E1a expression coul...

Topics

Adenoviridae
Adenovirus E1A Proteins
Animals
Antineoplastic Agents
Apoptosis
Carcinoma
Carcinoma, Squamous Cell
Cell Division
Cisplatin
DNA Damage
Doxorubicin
Drug Resistance, Neoplasm
Gamma Rays
HeLa Cells
Humans
Mice
Mutation
Radiation-Sensitizing Agents

Source

Open in PubMed

Identifiers

PMID: 8806698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8806698-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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