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Article

In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy.

Cancer research - 1 Mar 2000

Rogulski K R, Freytag S O, Zhang K, Gilbert J D, Paielli D L, Kim J H, Heise C C, Kirn D H

Abstract excerpt

The E1B-deleted, replication-competent ONYX-015 (dl1520) adenovirus was originally described as being able to selectively kill p53-deficient cells due to a requirement of p53 inactivation for efficient viral replication. This hypothesis has become controversial because subsequent in vitro studies have demonstrated that the host range specificity of ONYX-015 is independent of p53 gene status. Using a pair of...

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Identifiers

PMID: 10728673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vivo antitumor activity of ONYX-015 is influenced by p53 status and is augmented by radiotherapy.PMID 10728673Read ↗

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