Reversal of malignancy by the adenovirus E1a gene.

doi:10.1016/0027-5107(95)00103-4

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Article

Reversal of malignancy by the adenovirus E1a gene.

Mutation research - 19 Feb 1996

Frisch S M

Abstract excerpt

Tumor suppressor genes such as Rb and p53 usually kill tumor cells when overexpressed ectopically. This is a consequence of their normal cell cycle regulatory functions. By contrast, the E1a gene of adenovirus, a common cold virus, converts tumor cells into viable normal cells. This has advantage...

Topics

Adenovirus E1A Proteins
Apoptosis
Cell Adhesion Molecules
Cell Transformation, Neoplastic
Epithelial Cells
Epithelium
Genes, Viral
Humans
Mesoderm
Phenotype
Transcription, Genetic
Tumor Cells, Cultured

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