Article
Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport.
Molecular biology of the cell - 1 Nov 1999
Martin M, Iyadurai S J, Gassman A, Gindhart J G, Hays T S, Saxton W M
Abstract excerpt
In axons, organelles move away from (anterograde) and toward (retrograde) the cell body along microtubules. Previous studies have provided compelling evidence that conventional kinesin is a major motor for anterograde fast axonal transport. It is reasonable to expect that cytoplasmic dynein is a fast retrograde motor, but relatively few tests of dynein function have been reported with neurons of intact organisms....
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