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Article

Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.

PLoS biology - 1 Jul 2013

Lazarus Jacob E, Moughamian Armen J, Tokito Mariko K, Holzbaur Erika L F

Abstract excerpt

Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease. The microtubule motor cytoplasmic dynein and its partner complex dynactin drive retrograde transport from the distal axon. We have recently shown that the p150(Glued) subunit of dynactin promotes the initiation of dynein-driven cargo motility from the...

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PMID: 23874158
DOI: 10.1371/journal.pbio.1001611
PMCID: PMC3712912

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Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.PMID 23874158Read ↗

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