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Article

Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila.

Genetics - 1 Nov 1996

Hurd D D, Saxton W M

Abstract excerpt

Previous work has shown that mutation of the gene that encodes the microtubule motor subunit kinesin heavy chain (Khc) in Drosophila inhibits neuronal sodium channel activity, action potentials and neurotransmitter secretion. These physiological defects cause progressive distal paralysis in larvae. To identify the cellular defects that cause these phenotypes, larval nerves were studied by light and electron...

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Identifiers

PMID: 8913751
DOI: 10.1093/genetics/144.3.1075
PMCID: PMC1207603

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Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila.PMID 8913751Read ↗

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