Article
Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment.
Molecular biology of the cell - 1 Jun 2007
Haghnia Marjan, Cavalli Valeria, Shah Sameer B, Schimmelpfeng Kristina, Brusch Richard, Yang Ge, Herrera Cheryl, Pilling Aaron, Goldstein Lawrence S B
Abstract excerpt
Transport of cellular and neuronal vesicles, organelles, and other particles along microtubules requires the molecular motor protein dynein (Mallik and Gross, 2004). Critical to dynein function is dynactin, a multiprotein complex commonly thought to be required for dynein attachment to membrane compartments (Karki and Holzbaur, 1999). Recent work also has found that mutations in dynactin can cause the human motor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.