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Article

Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.

Journal of neuropathology and experimental neurology - 1 Nov 1999

Schmidt E E, Ichimura K, Goike H M, Moshref A, Liu L, Collins V P

Abstract excerpt

The genetic abnormality most frequently identified in glioblastomas is loss of alleles on chromosome 10. We have performed a comprehensive study of the PTEN tumor suppressor gene on 10q23, including loss of heterozygosity (LOH) analysis, multiplex PCR, mutation analysis, and reverse transcription PCR (RT-PCR). In total, 151 glioblastomas, 41 anaplastic astrocytomas, 15 astrocytomas, and 13 glioma cell lines were...

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Source

Identifiers

PMID: 10560660
DOI: 10.1097/00005072-199911000-00007

Genes

PTEN
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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