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Article

PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma Multiforme

15 Aug 2001

Abstract excerpt

BACKGROUND: Survival of patients with anaplastic astrocytoma is highly variable. Prognostic markers would thus be useful to identify clinical subsets of such patients. Because specific genetic alterations have been associated with glioblastoma, we investigated whether similar genetic alterations could be detected in patients with anaplastic astrocytoma and used to identify those with particularly aggressive...

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PMID: 11504770
DOI: 10.1093/jnci/93.16.1246

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Related research

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PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma MultiformePMID 11504770Read ↗

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Is exon 5 of the PTEN/MMAC1 gene a prognostic marker in anaplastic glioma?Semantic proximity Read ↗

PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas.Semantic proximity Read ↗

Molecular and clinical analysis of glioblastoma with an oligodendroglial component (GBMO).Semantic proximity Read ↗

Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors.Semantic proximity Read ↗

Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.Semantic proximity Read ↗

Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.Semantic proximity Read ↗

Prognostic stratification of patients with anaplastic gliomas according to genetic profileSemantic proximity Read ↗

Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations.Semantic proximity Read ↗

Analysis of loss of heterozygosity for chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survivalSemantic proximity Read ↗

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