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Article

Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.

The American journal of pathology - 1 Aug 1999

Fujisawa H, Kurrer M, Reis R M, Yonekawa Y, Kleihues P, Ohgaki H

Abstract excerpt

Loss of heterozygosity on chromosome 10 (LOH#10) is the most frequent genetic alteration in glioblastomas and occurs in more than 80% of cases. We recently reported that PTEN (MMAC1) on 10q23.3 is mutated in approximately 30% of primary (de novo) glioblastomas but rarely in secondary glioblastomas that progressed from low-grade or anaplastic astrocytomas. Because secondary glioblastomas also show LOH#10, tumor...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 10433932
DOI: 10.1016/S0002-9440(10)65135-8
PMCID: PMC1866845

Genes

PTEN
DMBT1
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.PMID 10433932Read ↗

PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas.Semantic proximity Read ↗

Molecular pathogenesis of malignant gliomas.Semantic proximity Read ↗

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.Semantic proximity Read ↗

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Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors.Semantic proximity Read ↗

Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.Semantic proximity Read ↗

Loss of Heterozygosity on Chromosome 19 in Secondary GlioblastomasSemantic proximity Read ↗

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Genetic and Biologic Progression in Astrocytomas and Their Relation to Angiogenic DysregulationSemantic proximity Read ↗

High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours.Semantic proximity Read ↗

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