Article
A novel germline mutation of PTEN associated with brain tumours of multiple lineages.
British journal of cancer - 20 May 2002
Staal F J T, van der Luijt R B, Baert M R M, van Drunen J, van Bakel H, Peters E, de Valk I, van Amstel H K P, Taphoorn M J B, Jansen G H, van Veelen C W M, Burgering B, Staal G E J
Abstract excerpt
We have identified a novel germline mutation in the PTEN tumour suppressor gene. The mutation was identified in a patient with a glioma, and turned out to be a heterozygous germline mutation of PTEN (Arg234Gln), without loss of heterozygosity in tumour DNA. The biological consequences of this germline mutation were investigated by means of transfection studies of the mutant PTEN molecule compared to wild-type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.