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Article

PIK3CA mutations in glioblastoma multiforme.

Acta neuropathologica - 1 Jun 2005

Hartmann Christian, Bartels Gesine, Gehlhaar Claire, Holtkamp Nikola, von Deimling Andreas

Abstract excerpt

Glioblastoma multiforme WHO grade IV is the most common and malignant variant of astrocytic tumors. Loss of heterozygosity of chromosome 10 and mutations in the tumor suppressor gene PTEN on 10q are molecular hallmarks of glioblastomas. Recently, mutations were identified in PIK3CA, encoding a pr...

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Source

Identifiers

PMID: 15924253
DOI: 10.1007/s00401-005-1000-1

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15924253-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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