Article
PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas.
Journal of neuropathology and experimental neurology - 1 Jul 1998
Tohma Y, Gratas C, Biernat W, Peraud A, Fukuda M, Yonekawa Y, Kleihues P, Ohgaki H
Abstract excerpt
Loss of heterozygosity (LOH) on chromosome 10 is the most frequent genetic alteration associated with the evolution of malignant astrocytic tumors and it may involve several loci. The tumor suppressor gene PTEN (MMAC1) on chromosome 10q23 is mutated in approximately 30% of glioblastomas (WHO Grad...
Topics
- Adult
- Aged
- Alternative Splicing
- Astrocytoma
- Brain Neoplasms
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- DNA Transposable Elements
- Exons
- Female
- Frameshift Mutation
- Gene Deletion
- Genes, Tumor Suppressor
- Glioblastoma
- Homozygote
- Humans
- Introns
- Male