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Article

Correlation between genetic alterations and growth of human malignant glioma xenografted in nude mice.

British journal of cancer - 15 Dec 2003

Leuraud P, Taillandier L, Aguirre-Cruz L, Medioni J, Crinière E, Marie Y, Dutrillaux A M, Kujas M, Duprez A, Delattre J-Y, Poupon M-F, Sanson M

Abstract excerpt

In order to develop preclinical models of malignant astrocytomas and oligodendrogliomas, a series of 54 resected gliomas (37 from oligodendroglial lineage and 17 from astrocytic lineage) were xenografted subcutaneously into nude mice. Molecular alterations commonly observed in gliomas subtypes, including LOH 1p and 1q, LOH 19q, LOH 10p and 10q, LOH 9p, TP53 and PTEN mutations, EGFR amplification, CDKN2A...

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Identifiers

PMID: 14676814
DOI: 10.1038/sj.bjc.6601466
PMCID: PMC2395278

Genes

EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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