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Article

Genetic profile, PTEN mutation and therapeutic role of PTEN in glioblastomas.

International journal of oncology - 1 Nov 2002

Fan Xing, Aalto Yan, Sanko Stephen G, Knuutila Sakari, Klatzmann David, Castresana Javier S

Abstract excerpt

New therapeutic strategies are needed to improve survival in glioblastoma (GBM) the most malignant astrocytic tumor. We evaluated: a) the genetic status of 22 GBMs by comparative genomic hybridization (CGH); b) the specific role of mutation and/or homozygous deletion of PTEN in the genesis of GBM; and c) the possible therapeutic role of PTEN against GBM, in vitro. CGH demonstrated that the most frequent region of...

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Source

Identifiers

PMID: 12370766

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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