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Article

Apolipoprotein E epsilon4 is associated with neuronal loss in the substantia nigra in Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2000

Camicioli R, Kaye J, Payami H, Ball M J, Murdoch G

Abstract excerpt

Apolipoprotein E epsilon4 (ApoE epsilon4) is associated with an earlier age at onset of Alzheimer's (AD) and possibly Parkinson's disease, suggesting a general role for ApoE epsilon4 in neuronal plasticity. Among 31 prospectively assessed subjects with pathologically confirmed AD (without Lewy bodies), epsilon4+ subjects had a longer duration of disease (by 2.8 years, p = 0.04). Only cell loss in the substantia...

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Identifiers

PMID: 10559556
DOI: 10.1159/000017186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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