Article
Regulation of lineage commitment distinct from positive selection.
Science (New York, N.Y.) - 5 Nov 1999
Keefe R, Dave V, Allman D, Wiest D, Kappes D J
Abstract excerpt
Developing alphabeta T cells diverge into the CD4 and CD8 lineages as they mature in the thymus. It is unclear whether lineage commitment is mechanistically distinct from the process that selects for the survival of T cells with useful T cell receptor (TCR) specificities (positive selection). In HD mice, which lack mature CD4+ T cells, major histocompatibility complex (MHC) class II-restricted T cells are...
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