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Article

CD8 lineage commitment in the absence of CD8.

Immunity - 1 May 1997

Goldrath A W, Hogquist K A, Bevan M J

Abstract excerpt

The absence of cytotoxic T lymphocyte activity and the failure of MHC class I-restricted T cell receptor (TCR) transgenic thymocytes to mature in CD8alpha-deficient mice suggest that CD8 may be essential for CD8 lineage commitment. We report that variants of the antigenic peptide that delete TCR transgenic thymocytes from CD8 wild-type but not CD8alpha-deficient mice can restore positive selection of CD8 lineage...

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Identifiers

PMID: 9175841
DOI: 10.1016/s1074-7613(00)80351-9
PMCID: PMC2782926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CD8 lineage commitment in the absence of CD8.PMID 9175841Read ↗

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Regulation of T cell fate by Notch.Semantic proximity Read ↗

Regulation of lineage commitment distinct from positive selection.Semantic proximity Read ↗

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Negative selection of thymocytes expressing the D10 TCR.Semantic proximity Read ↗

T cell development in CD8-/- mice. Thymic positive selection is biased toward the helper phenotype.Semantic proximity Read ↗

Visualization of CD4/CD8 T cell commitment.Semantic proximity Read ↗

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