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Article

NF-kappa B is required for the positive selection of CD8+ thymocytes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2000

Hettmann T, Leiden J M

Abstract excerpt

To examine the role of NF-kappaB in T cell development, we analyzed thymocyte ontogeny in transgenic (mutant I-kappaBalpha (mI-kappaBalpha)) mice that express a superinhibitory form of the NF-kappaB inhibitory protein, I-kappaBalpha (I-kappaBalpha(A32/36)), under the control of the T cell-specific CD2 promoter and enhancer. Thymi from mI-kappaBalpha mice contained increased numbers of double-positive (DP) and...

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Topics

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Share to Animals, Outbred Strains
Share to CD4 Antigens
Share to CD8 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to I-kappa B Proteins

Share to NF-KappaB Inhibitor alpha

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Thymus Gland

Source

Identifiers

PMID: 11046028
DOI: 10.4049/jimmunol.165.9.5004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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