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Article

A model for the origin of TCR-alphabeta+ CD4-CD8- B220+ cells based on high affinity TCR signals.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1999

Mixter P F, Russell J Q, Morrissette G J, Charland C, Aleman-Hoey D, Budd R C

Abstract excerpt

The origin of TCR-alphabeta+ CD4-CD8- cells is unclear, yet accumulating evidence suggests that they do not represent merely a default pathway of unselected thymocytes. Rather, they arise by active selection as evidenced by their absence in mice lacking expression of class I MHC. TCR-alphabeta+ CD4-CD8- cells also preferentially accumulate in mice lacking expression of Fas/APO-1/CD95 (lpr) or Fas-ligand (gld),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10229807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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