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Article

Role of the transcription factor Th-POK in CD4:CD8 lineage commitment.

Immunological reviews - 1 Feb 2006

Kappes Dietmar J, He Xi, He Xiao

Abstract excerpt

The molecular basis of CD4:CD8 lineage commitment, in particular the mechanism by which the precise correlation between lineage choice and T-cell receptor (TCR) specificity toward class I or II major histocompatibility complex is achieved, remains controversial. Both stochastic/selective and instructive models in various forms have been proposed to explain this correlation. The two main experimental approaches...

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Identifiers

PMID: 16448546
DOI: 10.1111/j.0105-2896.2006.00344.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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