Presenilins regulate alphabeta T cell development by modulating TCR signaling.

doi:10.1084/jem.20070550

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Article

Presenilins regulate alphabeta T cell development by modulating TCR signaling.

The Journal of experimental medicine - 3 Sept 2007

Laky Karen, Fowlkes B J

Abstract excerpt

TCRalphabeta signaling is crucial for the maturation of CD4 and CD8 T cells, but the role of the Notch signaling pathway in this process is poorly understood. Genes encoding Presenilin (PS) 1/2 were deleted to prevent activation of the multiple Notch receptors expressed by developing thymocytes. PS1/2 knockout thymocyte precursors inefficiently generate CD4 T cells, a phenotype that is most pronounced when...

Topics

Alleles
Animals
Antigens, CD
Antigens, Differentiation, T-Lymphocyte
CD4 Antigens
CD5 Antigens
Calcium
Cross-Linking Reagents
Gene Deletion
Histocompatibility Antigens
Integrases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lectins, C-Type

Ligands

Mice

Mice, Knockout

Presenilins

Receptors, Antigen, T-Cell, alpha-beta

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 17698590
DOI: 10.1084/jem.20070550
PMCID: PMC2118698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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