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Article

Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability.

Molecular and cellular biology - 1 May 2004

Liu Yuan, Zhang Haihua, Veeraraghavan Janaki, Bambara Robert A, Freudenreich Catherine H

Abstract excerpt

Flap endonuclease 1 (FEN1) is a central component of Okazaki fragment maturation in eukaryotes. Genetic analysis of Saccharomyces cerevisiae FEN1 (RAD27) also reveals its important role in preventing trinucleotide repeat (TNR) expansion. In humans such expansion is associated with neurodegenerative diseases. In vitro, FEN1 can inhibit TNR expansion by employing its endonuclease activity to compete with DNA ligase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15082797
DOI: 10.1128/MCB.24.9.4049-4064.2004
PMCID: PMC387768

Genes

FEN1
TNR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability.PMID 15082797Read ↗

Analysis of human flap endonuclease 1 mutants reveals a mechanism to prevent triplet repeat expansion.Semantic proximity Read ↗

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Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.Semantic proximity Read ↗

The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability.Semantic proximity Read ↗

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XPF mediates 3' flap processing for FEN1-independent Okazaki fragment maturation.Semantic proximity Read ↗

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