Article
A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Sun X, Perlick H A, Dietz H C, Maquat L E
Abstract excerpt
All eukaryotic cells analyzed have developed mechanisms to eliminate the production of mRNAs that prematurely terminate translation. The mechanisms are thought to exist to protect cells from the deleterious effects of in-frame nonsense codons that are generated by routine inefficiencies and inacc...
Topics
- Animals
- Base Sequence
- COS Cells
- Cell Nucleus
- Chlorocebus aethiops
- Codon, Nonsense
- Cytoplasm
- DNA Primers
- DNA, Complementary
- Fungal Proteins
- Gene Expression
- HeLa Cells
- Humans
- Mutation
- RNA Helicases