Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998

Sun X, Perlick H A, Dietz H C, Maquat L E

Abstract excerpt

All eukaryotic cells analyzed have developed mechanisms to eliminate the production of mRNAs that prematurely terminate translation. The mechanisms are thought to exist to protect cells from the deleterious effects of in-frame nonsense codons that are generated by routine inefficiencies and inaccuracies in RNA metabolism such as pre-mRNA splicing. Depending on the particular mRNA and how it is produced, nonsense...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Fungal Proteins

Share to Gene Expression

Share to Mutation

Share to RNA, Messenger

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 9707591
DOI: 10.1073/pnas.95.17.10009
PMCID: PMC21452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.PMID 9707591Read ↗

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinSemantic proximity Read ↗

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Semantic proximity Read ↗

Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts.Semantic proximity Read ↗

Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StorySemantic proximity Read ↗

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability.Semantic proximity Read ↗

Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p.Semantic proximity Read ↗

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).Semantic proximity Read ↗

UPF1-From mRNA Degradation to Human Disorders.Semantic proximity Read ↗

UPF3A and UPF3B are redundant and modular activators of nonsense-mediated mRNA decay in human cellsSemantic proximity Read ↗

Processing bodies are not required for mammalian nonsense-mediated mRNA decay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.