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Article

Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.

Developmental biology - 15 Sept 2014

Norrie Jacqueline L, Lewandowski Jordan P, Bouldin Cortney M, Amarnath Smita, Li Qiang, Vokes Martha S, Ehrlich Lauren I R, Harfe Brian D, Vokes Steven A

Abstract excerpt

Mutations in the Bone Morphogenetic Protein (BMP) pathway are associated with a range of defects in skeletal formation. Genetic analysis of BMP signaling requirements is complicated by the presence of three partially redundant BMPs that are required for multiple stages of limb development. We generated an inducible allele of a BMP inhibitor, Gremlin, which reduces BMP signaling. We show that BMPs act in a dose...

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Identifiers

PMID: 25034710
DOI: 10.1016/j.ydbio.2014.07.003
PMCID: PMC4143117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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