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Article

Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh).

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jan 2004

Sagai Tomoko, Masuya Hiroshi, Tamura Masaru, Shimizu Kunihiko, Yada Yukari, Wakana Shigeharu, Gondo Yoichi, Noda Tetsuo, Shiroishi Toshihiko

Abstract excerpt

Polarized expression of the Sonic hedgehog ( Shh) gene in the posterior mesenchyme is essential for pattern formation in the appendages of higher vertebrates, from teleost fins to tetrapod limb buds. We report on a sequence in intron 5 of the Lmbr1 gene, which resides approximately 1 Mb from the Shh coding region in the mouse genome and is highly conserved among teleost fishes and throughout the tetrapod lineage....

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Share to Conserved Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14727139
DOI: 10.1007/s00335-033-2317-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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