Article
Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb.
Nature - 23 Mar 1995
Parr B A, McMahon A P
Abstract excerpt
Formation of the vertebrate limb requires specification of cell position along three axes. Proximal-distal identity is regulated by the apical ectodermal ridge (AER) at the distal tip of the growing limb. Anterior-posterior identity is controlled by signals from the zone of polarizing activity (ZPA) within the posterior limb mesenchyme. Dorsal-ventral identity is regulated by ectodermally derived signals. Recent...
Topics
- Animals
- Extremities
- Gene Expression
- Gene Targeting
- Mesoderm
- Mice
- Mice, Inbred C57BL
- Mutation
- Signal Transduction
- Stem Cells