Article
Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects.
Molecular psychiatry - 1 Sept 1999
Gelernter J, Kranzler H, Cubells J
Abstract excerpt
The gene encoding the mu opioid receptor, OPRM1, contains at least two polymorphisms affecting protein sequence in exon 1, Ala6Val and Asp40Asn. In previous studies, each variant has been reported to be associated with some form of drug dependence. Although past reports have not been consistent, they have also not considered comparable populations. The goals of the present study were to delineate allele and...
Topics
- Adult
- Alcoholism
- Alleles
- Brain Chemistry
- Cocaine-Related Disorders
- Exons
- Female
- Gene Frequency
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium