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Article

Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1).

Alcoholism, clinical and experimental research - 1 Sept 1998

Kranzler H R, Gelernter J, O'Malley S, Hernandez-Avila C A, Kaufman D

Abstract excerpt

Opioidergic neurotransmission and, specifically, the mu opioid receptor have been implicated in the reinforcing effects of a variety of drugs of abuse. Consequently, the present study examined the association of a polymorphic (CA)n repeat at the OPRM1 locus (the gene coding for the mu opioid receptor) to alcohol or drug dependence in 320 Caucasian and 108 African-American substance-dependent or control subjects....

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Source

Identifiers

PMID: 9756053

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1).PMID 9756053Read ↗

Polymorphisms in the mu-opioid receptor gene (OPRM1) and the implications for alcohol dependence in humans.Semantic proximity Read ↗

Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.Semantic proximity Read ↗

Mu opioid receptor gene variants: lack of association with alcohol dependence.Semantic proximity Read ↗

Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.Semantic proximity Read ↗

Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.Semantic proximity Read ↗

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.Semantic proximity Read ↗

Initial evidence of an association between OPRM1 and adolescent alcohol misuse.Semantic proximity Read ↗

A single nucleotide polymorphism in OPRM1(rs483481) and risk for heroin use disorder.Semantic proximity Read ↗

Influence of the OPRM1 A118G polymorphism on alcohol-induced euphoria, risk for alcoholism and the clinical efficacy of naltrexone.Semantic proximity Read ↗

Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects.Semantic proximity Read ↗

Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population.Semantic proximity Read ↗

A genetic association study of the mu opioid receptor and severe opioid dependence.Semantic proximity Read ↗

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