Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1).

Article

Association of alcohol or other drug dependence with alleles of the mu opioid receptor gene (OPRM1).

Alcoholism, clinical and experimental research - 1 Sept 1998

Kranzler H R, Gelernter J, O'Malley S, Hernandez-Avila C A, Kaufman D

Abstract excerpt

Opioidergic neurotransmission and, specifically, the mu opioid receptor have been implicated in the reinforcing effects of a variety of drugs of abuse. Consequently, the present study examined the association of a polymorphic (CA)n repeat at the OPRM1 locus (the gene coding for the mu opioid rece...

Topics

Adult
Alcoholism
Alleles
Chromosome Mapping
Female
Gene Frequency
Humans
Male
Middle Aged
Phenotype
Polymorphism, Genetic
Receptors, Opioid, mu
Substance-Related Disorders

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