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Article

Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.

Human molecular genetics - 15 Mar 2006

Zhang Huiping, Luo Xingguang, Kranzler Henry R, Lappalainen Jaakko, Yang Bao-Zhu, Krupitsky Evgeny, Zvartau Edwin, Gelernter Joel

Abstract excerpt

We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of the mu-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol dependence (AD) and/or drug dependence (DD)] and 338 EA healthy controls. These SNPs delineated two haplotype blocks. Genotype distributions for all SNPs were in Hardy-Weinberg equilibrium (HWE) in controls, but in...

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Source

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Identifiers

PMID: 16476706
DOI: 10.1093/hmg/ddl024
PMCID: PMC3164878

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.PMID 16476706Read ↗

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