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Article

Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2003

Luo Xingguang, Kranzler Henry R, Zhao Hongyu, Gelernter Joel

Abstract excerpt

Our objective was to investigate the relationship between the gene encoding the mu-opioid receptor (OPRM1) and susceptibility to substance dependence in European-American (EA) and African-American (AA) subjects. Eight single nucleotide polymorphisms (SNPs) at the OPRM1 locus, i.e., -2044C/A, -1793T/A, -1699insT, -1469T/C, -1320A/G, -111C/T, +17C/T (Ala6Val), and +118A/G (Asn40Asp) were genotyped in 676 subjects:...

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Identifiers

PMID: 12815747
DOI: 10.1002/ajmg.b.20034

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans.PMID 12815747Read ↗

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