Article
Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations.
Drug and alcohol dependence - 1 Jan 2013
Crist R C, Ambrose-Lanci L M, Vaswani M, Clarke T K, Zeng A, Yuan C, Ferraro T N, Hakonarson H, Kampman K M, Dackis C A, Pettinati H M, O'Brien C P, Oslin D W, Doyle G A, Lohoff F W, Berrettini W H
Abstract excerpt
BACKGROUND: Addiction susceptibility and treatment responsiveness are greatly influenced by genetic factors. Sequence variation in genes involved in the mechanisms of drug action have the potential to influence addiction risk and treatment outcome. The opioid receptor system is involved in mediating the rewarding effects of cocaine and opioids. The μ-opioid receptor (MOR) has traditionally been considered the...
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