Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence.

doi:10.1007/s004390000340

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Article

Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence.

Human genetics - 1 Jul 2000

Gelernter J, Kranzler H R

Abstract excerpt

The three opioid receptor genes, and in particular the mu and delta loci (OPRM1 and OPRD1, respectively), are compelling candidates to influence risk for substance dependence. Previous study of a variant at the OPRD1 locus, T921C, has shown association with opioid dependence. This variant does not alter protein sequence, and could not be directly responsible for a physiologic effect. We sequenced the OPRD1 coding...

Topics

Alleles
Gene Frequency
Genetics, Population
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Polymorphism, Genetic
Receptors, Opioid, delta
Substance-Related Disorders

Source

Open in PubMed

Identifiers

PMID: 10982041
DOI: 10.1007/s004390000340

Genes

OPRD1
OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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