Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.

Cancer research - 1 Oct 1999

Bruening W, Prowse A H, Schultz D C, Holgado-Madruga M, Wong A, Godwin A K

Abstract excerpt

Loss of all or part of one copy of chromosome 17p is very common in ovarian and breast tumors. OVCA1 is a candidate tumor suppressor gene mapping to a highly conserved region on chromosome 17p13.3 that shows frequent loss of heterozygosity in breast and ovarian carcinomas. Western blot analysis of extracts prepared from breast and ovarian carcinomas revealed reduced expression of OVCA1 compared with extracts from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Chromosomes, Human, Pair 17

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Loss of Heterozygosity

Share to Minor Histocompatibility Antigens

Share to Ovarian Neoplasms

Share to Polymorphism, Single-Stranded Conformational

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 10519411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.PMID 10519411Read ↗

Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis.Semantic proximity Read ↗

Identification of two candidate tumor suppressor genes on chromosome 17p13.3.Semantic proximity Read ↗

Establishment and characterization of xenografts and cancer cell cultures derived from BRCA1 -/- epithelial ovarian cancers.Semantic proximity Read ↗

VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer.Semantic proximity Read ↗

The ovarian tumor protein isoforms of Drosophila melanogaster exhibit differences in function, expression, and localization.Semantic proximity Read ↗

Allelic deletion on chromosome 17p13.3 in early ovarian cancer.Semantic proximity Read ↗

Ovca1, a candidate gene of the genetic modifier of Tp53, Mop2, affects mouse embryonic lethality.Semantic proximity Read ↗

Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma.Semantic proximity Read ↗

Poor correlation with loss of heterozygosity on chromosome 17p and p53 mutations in ovarian cancers.Semantic proximity Read ↗

Frequent Loss of pRb2/p130 in Human Ovarian CarcinomaSemantic proximity Read ↗

Absence of prohibitin gene mutations in human epithelial ovarian tumors.Semantic proximity Read ↗

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.