Article
Allelic deletion on chromosome 17p13.3 in early ovarian cancer.
Cancer research - 1 Feb 1996
Phillips N J, Ziegler M R, Radford D M, Fair K L, Steinbrueck T, Xynos F P, Donis-Keller H
Abstract excerpt
Multiple chromosome 17 loci may be involved in ovarian carcinogenesis. Fifty-seven sporadic ovarian epithelial tumors were examined for loss of heterozygosity at 15 loci on chromosomes 17p. Eighty % (39 of 49) of informative tumors had allelic loss in 17p13.3 at D17S30, D17S28, or both loci within this region, including 3 of 7 tumors of low malignant potential and 4 of 5 nonmetastatic carcinomas. The smallest...
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