Article
VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer.
Molecular oncology - 1 Jun 2013
Gambaro Karen, Quinn Michael C J, Wojnarowicz Paulina M, Arcand Suzanna L, de Ladurantaye Manon, Barrès Véronique, Ripeau Jean-Sébastien, Killary Ann M, Davis Elaine C, Lavoie Josée, Provencher Diane M, Mes-Masson Anne-Marie, Chevrette Mario, Tonin Patricia N
Abstract excerpt
Previous studies have implicated vestigial like 3 (VGLL3), a chromosome 3p12.3 gene that encodes a putative transcription co-factor, as a candidate tumor suppressor gene (TSG) in high-grade serous ovarian carcinomas (HGSC), the most common type of epithelial ovarian cancer. A complementation analysis based on microcell-mediated chromosome transfer (MMCT) using a centric fragment of chromosome 3 (der3p12-q12.1)...
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