Article
An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.
Cancer research - 1 Oct 1992
Campbell I G, Freemont P S, Foulkes W, Trowsdale J
Abstract excerpt
The monoclonal antibody OVTL3 has a highly restricted reactivity with ovarian carcinomas and defines a surface glycoprotein, OA3, which has been used for immunotargeting. To understand why OA3 is found on ovarian tumors we isolated a complementary DNA by expression cloning. The clone encodes a 323-amino acid protein with 5 putative membrane spanning domains, reminiscent of a membrane receptor or channel, but of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.