An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.

Cancer research - 1 Oct 1992

Campbell I G, Freemont P S, Foulkes W, Trowsdale J

Abstract excerpt

The monoclonal antibody OVTL3 has a highly restricted reactivity with ovarian carcinomas and defines a surface glycoprotein, OA3, which has been used for immunotargeting. To understand why OA3 is found on ovarian tumors we isolated a complementary DNA by expression cloning. The clone encodes a 323-amino acid protein with 5 putative membrane spanning domains, reminiscent of a membrane receptor or channel, but of a...

Topics

Amino Acid Sequence
Antigens, Neoplasm
Base Sequence
Biomarkers, Tumor
Blotting, Southern
Cloning, Molecular
DNA, Neoplasm
DNA, Recombinant
Female
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Membrane Proteins

Molecular Sequence Data

Ovarian Neoplasms

RNA Splicing

RNA, Messenger

Sequence Homology

Source

Open in PubMed

Identifiers

PMID: 1394148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1394148-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains.PMID 1394148Read ↗

VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer.Semantic proximity Read ↗

Molecular Cloning of the CA125 Ovarian Cancer AntigenSemantic proximity Read ↗

Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.Semantic proximity Read ↗

Ovarian cancer antigen CA125 is encoded by the <i>MUC16</i> mucin geneSemantic proximity Read ↗

Expression status and prognostic significance of mitochondrial dynamics OPA3 in human ovarian cancerSemantic proximity Read ↗

Immunotherapeutic Approaches in Ovarian CancerSemantic proximity Read ↗

Identification of two candidate tumor suppressor genes on chromosome 17p13.3.Semantic proximity Read ↗

Profiling extracellular vesicles in circulation enables the early detection of ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.