Identification of two candidate tumor suppressor genes on chromosome 17p13.3.

Article

Identification of two candidate tumor suppressor genes on chromosome 17p13.3.

Cancer research - 1 May 1996

Schultz D C, Vanderveer L, Berman D B, Hamilton T C, Wong A J, Godwin A K

Abstract excerpt

A second tumor suppressor locus on 17p that is distinct from TP53 has been identified in brain, breast, lung, and ovarian tumors. Using allelic loss mapping and positional cloning methods, we have recently identified two novel genes, which we refer to as OVCA1 and OVCA2, that map to 17p13.3. The...

Topics

Alleles
Amino Acid Sequence
Animals
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Genes, Tumor Suppressor
Genetic Markers
Humans
Molecular Sequence Data
Ovarian Neoplasms
Rats
Tumor Cells, Cultured

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