Article
Establishment and characterization of xenografts and cancer cell cultures derived from BRCA1 -/- epithelial ovarian cancers.
European journal of cancer (Oxford, England : 1990) - 1 Jul 2006
Indraccolo Stefano, Tisato Veronica, Agata Simona, Moserle Lidia, Ferrari Silvia, Callegaro Monia, Persano Luca, Palma Maurizia Dalla, Scaini Maria Chiara, Esposito Giovanni, Fassina Ambrogio, Nicoletto Ornella, Plebani Mario, Chieco-Bianchi Luigi, Amadori Alberto, D'Andrea Emma, Montagna Marco
Abstract excerpt
The BRCA1 gene is responsible for a high number of hereditary breast and ovarian cancers that cluster in families with a strong genetic predisposition. Despite intense investigation, the accumulating findings on BRCA1 biological functions have not yet been translated into specific therapeutic approaches, also due to the lack of suitable experimental models. The purpose of this study was to establish and...
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