Article
Rev-mediated nuclear export of RNA is dominant over nuclear retention and is coupled to the Ran-GTPase cycle.
Nucleic acids research - 1 Nov 1999
Fischer U, Pollard V W, Lührmann R, Teufel M, Michael M W, Dreyfuss G, Malim M H
Abstract excerpt
The human immunodeficiency virus type-1 Rev protein induces the nuclear export of intron-containing viral mRNAs that harbor its binding site, the Rev response element (RRE). A leucine-rich region of Rev, the activation domain, is essential for function and has been shown to be a nuclear export signal (NES). Although Rev exports viral RNAs that resemble cellular mRNAs, competition studies performed using...
Topics
- Animals
- Biological Transport
- COS Cells
- Cell Nucleus
- Consensus Sequence
- Exons
- Gene Products, rev
- Gene Products, tat
- HIV-1
- Heterogeneous Nuclear Ribonucleoprotein A1
- Heterogeneous-Nuclear Ribonucleoprotein Group A-B
- Heterogeneous-Nuclear Ribonucleoproteins
- Introns