An anti-apoptotic protein, Hax-1, inhibits the HIV-1 rev function by altering its sub-cellular localization.

doi:10.1002/jcp.21305

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Article

An anti-apoptotic protein, Hax-1, inhibits the HIV-1 rev function by altering its sub-cellular localization.

Journal of cellular physiology - 1 Jan 2008

Modem Suhasini, Reddy Thipparthi R

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the nuclear export of viral mRNA containing the Rev response element (RRE). Although several host proteins co-operating with Rev in viral RNA export have been reported, little is known about the innate host defense factors that Rev overcomes to mediate the nuclear export of unspliced viral mRNAs. We report here that an anti-apoptotic protein,...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Motifs
Animals
Apoptosis
COS Cells
Cell Nucleus
Cells, Cultured
Chloramphenicol O-Acetyltransferase
Chlorocebus aethiops
Cytoplasm
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Viral

Gene Products, rev

Glutathione Transferase

HIV-1

Humans

Mutation

Plasmids

Source

Open in PubMed

Identifiers

PMID: 17929250
DOI: 10.1002/jcp.21305

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