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Rous Sarcoma Virus DR Posttranscriptional Elements Use a Novel RNA Export Pathway

15 Oct 2000

Abstract excerpt

Rous sarcoma virus (RSV), a simple retrovirus, needs to export unspliced viral RNA from the nucleus to the cytoplasm, circumventing the host cell restriction on cytoplasmic expression of intron-containing RNA. The cytoplasmic accumulation of full-length viral RNA is promoted by two cis-acting direct repeat (DR) elements that flank the src gene; at least one copy of the DR sequence is necessary for viral...

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PMID: 11000220
DOI: 10.1128/jvi.74.20.9507-9514.2000

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