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Article

Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.

PloS one - 1 Jan 2012

Hoffmann Dirk, Schwarck Doreen, Banning Carina, Brenner Matthias, Mariyanna Lakshmikanth, Krepstakies Marcel, Schindler Michael, Millar David P, Hauber Joachim

Abstract excerpt

The HIV-1 Rev trans-activator is a nucleocytoplasmic shuttle protein that is essential for virus replication. Rev directly binds to unspliced and incompletely spliced viral RNA via the cis-acting Rev Response Element (RRE) sequence. Subsequently, Rev oligomerizes cooperatively and interacts with the cellular nuclear export receptor CRM1. In addition to mediating nuclear RNA export, Rev also affects the stability,...

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Identifiers

PMID: 22675540
DOI: 10.1371/journal.pone.0038305
PMCID: PMC3366918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains.PMID 22675540Read ↗

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