Article
Nucleocytoplasmic transport of the Rev protein of human immunodeficiency virus type 1 is dependent on the activation domain of the protein.
Experimental cell research - 1 Mar 1995
Wolff B, Cohen G, Hauber J, Meshcheryakova D, Rabeck C
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev, which is required for the cytoplasmic expression of unspliced and incompletely spliced viral mRNAs, is located predominantly in the nucleolus. In this study, we show that Rev translocates from the nucleolus to the cytoplasm i...
Topics
- Amino Acid Sequence
- Biological Transport
- Cell Line
- Cell Nucleus
- Cytoplasm
- Dactinomycin
- Fluorescent Antibody Technique
- Gene Products, rev
- HIV-1
- HeLa Cells
- Humans
- Image Processing, Computer-Assisted
- Molecular Sequence Data
- Mutation
- Protein Sorting Signals
- RNA Polymerase I
- RNA, Ribosomal
- Regulatory Sequences, Nucleic Acid