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Article

Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.

The EMBO journal - 1 Sept 1994

Fischer U, Meyer S, Teufel M, Heckel C, Lührmann R, Rautmann G

Abstract excerpt

The Rev trans-activator of human immunodeficiency virus type 1 (HIV-1) is a protein that regulates the simultaneous appearance in the cytoplasm of both spliced and unspliced forms of viral mRNAs from the same viral transcripts by way of recognition of a target sequence termed the Rev-responsive element (RRE). Whether Rev acts directly on RNA export or by inhibition of splicing, or both, is still a matter of...

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Identifiers

PMID: 8076606
DOI: 10.1002/j.1460-2075.1994.tb06728.x
PMCID: PMC395333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.PMID 8076606Read ↗

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Nucleocytoplasmic transport of the Rev protein of human immunodeficiency virus type 1 is dependent on the activation domain of the protein.Semantic proximity Read ↗

The HIV-1 Rev protein enhances encapsidation of unspliced and spliced, RRE-containing lentiviral vector RNA.Semantic proximity Read ↗

Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin.Semantic proximity Read ↗

Tap and Dbp5, but not Gag, are involved in DR-mediated nuclear export of unspliced Rous sarcoma virus RNA.Semantic proximity Read ↗

Epstein-Barr Virus EB2 Protein Exports Unspliced RNA via a Crm-1-Independent PathwaySemantic proximity Read ↗

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The interactions with Ro60 and La differentially affect nuclear export of hY1 RNA.Semantic proximity Read ↗

Rev proteins of human and simian immunodeficiency virus enhance RNA encapsidation.Semantic proximity Read ↗

Effect of Rev on the intranuclear localization of HIV-1 unspliced RNA.Semantic proximity Read ↗

Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta.Semantic proximity Read ↗

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