Article
Cofactor requirements for nuclear export of Rev response element (RRE)- and constitutive transport element (CTE)-containing retroviral RNAs. An unexpected role for actin.
The Journal of cell biology - 5 Mar 2001
Hofmann W, Reichart B, Ewald A, Müller E, Schmitt I, Stauber R H, Lottspeich F, Jockusch B M, Scheer U, Hauber J, Dabauvalle M C
Abstract excerpt
Nuclear export of proteins containing leucine-rich nuclear export signals (NESs) is mediated by the export receptor CRM1/exportin1. However, additional protein factors interacting with leucine-rich NESs have been described. Here, we investigate human immunodeficiency virus type 1 (HIV-1) Rev-mediated nuclear export and Mason-Pfizer monkey virus (MPMV) constitutive transport element (CTE)-mediated nuclear export...
Topics
- Actins
- Active Transport, Cell Nucleus
- Animals
- Carrier Proteins
- Cytoplasm
- Gene Products, rev
- HIV-1
- HeLa Cells
- Humans
- Intracellular Signaling Peptides and Proteins