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Article

Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005

Furuta Saori, Jiang Xianzhi, Gu Bingnan, Cheng Eric, Chen Phang-Lang, Lee Wen-Hwa

Abstract excerpt

Cumulative evidence indicates that breast cancer-associated gene 1 (BRCA1) participates in DNA damage repair and cell-cycle checkpoint control, serving as a tumor susceptibility gene to maintain the global genomic stability. However, whether BRCA1 has a direct role in cell proliferation and differentiation, two key biological functions in tumorigenesis, remains unclear. Here we demonstrate BRCA1 mediates...

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Source

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Identifiers

PMID: 15967981
DOI: 10.1073/pnas.0503793102
PMCID: PMC1166629

Genes

BRCA1
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.PMID 15967981Read ↗

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BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.Semantic proximity Read ↗

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